So sorry you are feeling bad and that Tobramycin isn't working. Is Tobramycin the same as Amikacin do you know? When I started Amikacin inhalation I lost my voice entirely for a week or two and had a sore throat. My voice came back after a couple of weeks but was hoarse. After I stopped my voice went back to normal. I'm so sorry you are now resistant to most of the antibiotics. Best to you.