Replies to Hello. I have bad bilateral sensory neuropathy in feet and ankles for eighteen years. I recently…

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Neuropathy | Last Active: May 7 12:13pm | Replies (294)

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@margaret10

Hello. I have bad bilateral sensory neuropathy in feet and ankles for eighteen years. I recently learned that I have a non-conservative mutation in my SDHB gene (which is responsible for a pheochromocytoma I had many years ago). For years, I've had elevated serum B6 even though I don't take B6 supplement. Could the mutated SDHB gene be responsible for my elevated B6 and/or neuropathy? Many thanks for àny clues.

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Replies to "Hello. I have bad bilateral sensory neuropathy in feet and ankles for eighteen years. I recently..."

John, Volunteer Mentor | @johnbishop | Mar 21, 2020

Hello @margaret10 -- Welcome to Mayo Clinic Connect. I'm hoping other members may be able to help you with your search. It is good to be learning as much as you can about your condition. Here are a few articles I found that may be helpful.

Disorders affecting vitamin B6 metabolism -- https://onlinelibrary.wiley.com/doi/full/10.1002/jimd.12060
Elevated B6 Levels and Peripheral Neuropathies -- https://pubmed.ncbi.nlm.nih.gov/18754531/
Linus Pauling Institute - Vitamin B6 -- https://lpi.oregonstate.edu/mic/vitamins/vitamin-B6

Have your doctors suggested any possible treatments for your elevated B6 levels?

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