I’ve got double copy mthfr 0677 tt I only have 30 function of absorption of folate b12. I too have taken a lot of b6 because it’s needed for absorption with folate b12. FYI. With this gene only take Methylfolate and Methylcobaline Crk spelling . Other formulas will not be absorbed. Never take folic acid as your body can not absorb with this gene therefore the folic acid just floats around un used wasted causing toxic build up causing more symptoms with the mutation. I’ve searched for 15 years to find someone who knew how to help me manage this. Doctor are not taught about nutrition. They clearly have no education in gene issue that involve nutrition or dna. I pray you can find a doctor who knows about this gene I’ve been my own doctor and was doing ok with it until this b6 toxicity. Not only do I have neuropathy from being deficient for a life time but the b6 has caused all body parts to not function. Muscle never coordination I’ve learned a lot about the mutation but your welcome to contact me. I’ll share what I know. I’m new to this platform so not sure how to navigate. Sorry for my typo. I can’t feel my hands. My neurologist sent me home with a Rx of peripheral neuropathy saying my b12 looked fine. Years later learned blood test only show what’s in your blood. It fails to show how much you are capable of absorbing. There are some formulas that can better help show your absorption levels. So mthfr people must maintain higher than normal levels of folate and b12. Don’t don’t know this. It’s a tricky trial an error knowing your sweet spots. Wish you could find could help. Tallahassee is clueless here. Wish you best and sending you prayers