Hi @gman007 - I agree that each person should discuss with their doctor before taking a lot of any vitamin/supplement. If there is any question, it's always a good idea to discuss it with your doctor or a pharmacist and know what you are taking. The problem with B6 is that it is different than other B vitamins when it comes to being water soluble. Unlike most B vitamins, B6 does not simply wash out of your system in the urine. So if you have a health problem that's affecting levels of B6 in your body and you take multivitamins and other supplements with a lot of B6 in them it can lead to B6 toxicity and cause a lot of healthy issues - one being peripheral neuropathy. I don't have any medical training or background but know this through research and others who have been affected by high levels of B6 in their system.

John