ive been taking tramadol for years, as needed. for me it is minimal help on the pain and i get a 48 hour hangover from it. due to bad stomach it is about the only strong pain reliever i can tolerate. i take 100mg 3 times per day sometimes. i hate the hangover. im also on methotrexate maximum injection weekly and celebrex 200mg twice a day, and gabapenton 300mg four times a day.