@strokemyoak. I can relate to the type of pain you are experiencing. I've had multiple joint replacements,(knees and shoulders) but within the last year began having a sharp pain in the lumbar area going down my right leg and to my outer calf. I had an MRI and was diagnosed with spondylolisthesis where one vertebra has slipped out of alignment. I used to be very active but that sharp pain keeps me from doing much. I get the pain especially when I walk. I go to PT and follow the exercises to strengthen my core. So far, the only thing I have found that works is bilateral cortisone injections at the facets of L5 and S1. I can have 3/year. The last one gave me 90% relief for a month then gradually less relief until now at 3 months I'm scheduled for more injections. To @robbinr, I didn't know you could have stem cell/plasma injections for vertebral pain. Could you tell me more about where one would go to try this? I find insurance is a real stickler when it comes to even the cortisone injections. Would this be considered experimental? Thanks