I was diagnosed by a rheumatologist in November with drug-induced lupus and raynauds due to chlorthalidone and possibly lisinopril, which was discontinued. Since then, I have reacted to other antihypertensives, i.e., ARBs, ACES, calcium channel blockers, loop diuretics. Within 3-4 weeks of taking the new bp medications, I have painful flare-ups and have to stop taking them. I'm in my 2nd week of starting a new drug. I hope and pray there is no flare-up. My doctor is referring me to a nephrologist after I get a renal U/S and doppler flow. My kidney functions in October were normal. I think my doctor is just as frustrated as I am. We're running out of options with the antihypertensives. I'd appreciate any input and suggestions.