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Other causes of failed PEth test for alcohol abuse?

Mental Health | Last Active: Jun 13 10:51am | Replies (436)

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@yorkie0727

I joined specifically to comment in this group. I have regular and random alcohol use screening from two separate providers. I consistently pass GGT and CDT test but one provider decided to give me a PEth and Ethyl Glucuronide test. I passed the Ethyl Glucuronide test but had a 653 ng/mL PEth result well above the 20 ng/mL cutoff. Slightly worried and working on my rebuttal. Although this provider is not my primary care physician who actually handles and controls my case she can influence him. I just had an appointment with him and he has little concern about my abstinence. However, non-FDA approved testing can derail that apparently according to peoples posts.

I wanted to share this, it came directly from my lab results which I have full access to:
"Comments: Analyzed compound: PEth 16:0/18:1. 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol. Analysis performed by Liquid Chromatography with Tandem Mass Spectrometry (LC/MS/MS). Detection limit: 20 ng/mL PEth levels in excess of 20 ng/mL are considered evidence of moderate to heavy ethanol consumption. However, the Center for Substance Abuse Treatment (CSAT) advises caution in interpretation and use of biomarkers alone to assess alcohol use. Results should be interpreted in the context of all available clinical and behavioral information. Reference: Substance Abuse and Mental Health Services Administration (2012). \"The Role of Biomarkers in the Treatment of Alcohol Use Disorders\", 2012 Revision. Advisory, Volume 11, Issue 2. This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration."

I hope the comments will help someone else bolster their case as to the lack of validity using PEth as a sole biomarker.

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Replies to "I joined specifically to comment in this group. I have regular and random alcohol use screening..."

I can tell you there are at least a couple people on this forum I am confident were railroaded by bad PETH tests from LabCorp. Interestingly the two I am personally aware of both were tested at the same testing facility (in Dallas) but passed the exact same LabCorp tests at other testing facilities the same/next day. What I cannot tell you is if the issue is the LabCorp test or the test facility... but something with these tests are definitely wrong. I would strongly encourage you to go take the PETH again somewhere else (even if they use LabCorp as the backend) and compare the results. Depending on the timelines for doing so you can make the argument that it could have naturally fallen but if you are taking it close together - ideally the same day - it is pretty hard to argue something is not wrong wit the test. Of note there are also blood-drawn (e.g. using a vial vs a finger prick card) that also have produced good results for us while failing the LabCorp test. Request-a-Test as example does this test. PM me if you need more info or if you happen to be failing the test in Dallas as I would like to compare notes with you. I would also be interested in if you take the LabCorp test somewhere else and pass it on the same/next day if you have to take the test again.

The manufacturer itself says that a level of 100 nag/mL represents two binge sessions per day for 30 days. How is that even possible???