Hi @heidi1346 and welcome to Mayo Clinic Connect. It sounds like Trintellix (vortioxetine) is causing several digestive related issues for you, including nausea, upset stomach and severe diarrhea. Nausea is the most common side effect of this drug. I'd like to bring @rossjt @marjou @trip17 @elwooodsdad @petangelkat1 @jeanmnyc @marazion @alamogal635 and @kelster69 into this discussion so they can share their experiences with you.

While we wait for others to join in the discussion, you may also wish to see this discussion thread:
- Switching to Trintellix or Low Dose Naltrexone (LDN) https://connect.mayoclinic.org/discussion/trintillix/

Heidi, have you discussed the side effects you're experiencing with your doctor? How long have you been taking Trintellix? What dosage?