..just happened to get notification of your question so don't want to interfere as not on it nor been on it, (never heard of it before) but I did just check on Internet and it is listed (diarrhea) as a common side effect, but also says to tell your Doctor if you get this side effect......although I have not taken it I have IBS-D, C.Diff and now fecal incontinence/diarrhea daily and I hope that it does go away for you as it's horrible to live with. I also get it with all antibiotics... and when we are on antibiotics we cannot take anti-diarrhea meds!!! ......so wishing you the best outcome.... J.S.

@heidi1346 , I was on Trintillex for about 6 weeks last summer. I did have nausea when I started taking it, and my doctor prescribed an anti-nausea I could take with it. That said, I started to tolerate the drug better after a couple of weeks. No diarrhea, but if the Trintillex works for your depression, maybe you could talk to your doctor about taking something to stop your diarrhea. I've learned that if you find something that helps you, it's worth putting up with the side effects (to a reasonable extent). Depression is hell and anything that you can arm yourself with to fight it is worth trying. All the best to you.