@ginger38314 that was sort of my take until the RO said "there is an absolute benefit and the toxicity from a 6 month course of ADT is temporary". The Decipher studies that show a 8-10% benefit of adding ADT lump intermediate and high risk decipher scores into the same bucket. And its impossible to tell within that bucket who is getting the bigger benefit and who isn't. The study does show an absolute benefit and in his mind even with a strong baseline it is worth the temporary side effects of ADT. My baseline is a 95.3% chance of being metastatic free in 10yrs. I was initially resistant to that but now I'm more accepting of that philosophy and trying to intervene to avoid the worst ADT side effects.