@riley5634 Oh I don't take it with pear juice..I take it in water..I drink pear juice (acts like prune juice but tastes so much better..lol!!) Sometimes my sugar "drops" and it works for this too (not diabetic but it just does)..today I am cleaning out with 2 Bisacodyl's..and feeling sort of exhausted..I used to take Trulance and it worked fine for me until I got this Xolair shot.. tied Linzess, Amtiza and Isbrella made me sick or didn't work.. very sensitive to meds.. so I'm hoping this Xolair shot will wear odd (it takes months ) and things will get back to normal.. Trulance really worked very well for me.. 3-5 times a day ..no problem.. perfect.. it was Heaven:) You might ask your gastro about it.. and of course hydrate..hydrate hydrate (I'm not so good at that..continued prayers for all of us!! God bless you!!