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PC spread to some lymph nodes; radiation, ADT. intermittent ADT
Prostate Cancer | Last Active: Oct 14 5:37am | Replies (72)Comment receiving replies
@pesquallie Be careful. Were these observational studies of men with naturally low testosterone, or randomized studies comparing mortality in prostate cancer patients receiving ADT versus those not receiving ADT? Because those are two very different questions. ADT reduces all cause mortality in men with prostate cancer. However, discussions about when and how much to treat are appropriate.
Replies to "@pesquallie Be careful. Were these observational studies of men with naturally low testosterone, or randomized studies..."
The three studies I read all saw a 40% increase in mortality for low testosterone patients in the general population. Only one study also looked separately at those who had used ADT and it also showed a 40% reduction in life expectancy.
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@dhasper In Nov 2025 JAMA a review of many studies with 10K+ (7K+ advanced) found that patients treated for local or regional prostate cancer ADT longer than 12 months continued to increase PCa specific survival, and time before recurrence and/or metastasis but overall survival decreased. For intermediate PCa the breakpoint was about 6 months of ADT. These are patients that were treated and went into remission so no need to continue ADT. Patients that have metastatic PCa will obviously survive longer on ADT as long as they are castrate sensitive.