@graydude Most of us who use compression socks probably do so to prevent blood pooling in our lower extremities, i.e. legs etc. where gravity is a factor. That factor disappears when we're lying flat.

From Web MD: https://www.webmd.com/dvt/choose-compression-stockings

Should you sleep with compression stockings?
For over-the-counter compression socks, there’s often no benefit to wearing them overnight. Taking them off overnight gives your skin a break to avoid damage.
If you have prescribed compression stockings for medical use, your doctor may tell you to wear them overnight. When it comes to sleeping in compression stockings, follow your doctor’s advice.
My own doctor advises NOT to do it. Your own mileage may vary.