I started hrt at 66, 14 years post menopause. I did my research and took it to the endocrinologist. After going through my labs for the past 6 or 7 years she said I was a perfect candidate for hrt. I have low breast cancer risk. I always have high good cholesterol and low bad cholesterol. I eat a plant based diet and excercise daily. I'm using the .025 patch and 100 mg progesterone pill. I sleep better, my lipo protein A, which was 1 point out of range lowered significantly. I also started Tymlos one month after hrt and have a great response so far, starting month 10. I hope to maintain my gains with just hrt.