@katdens trial and error , right? Yes, I have discovered with at least trying 20 different topicals (from prescription to OTC) that aspercream is most effective for me. It only lasts15-20 mins, but it’s 15-20 mins! I also like Vicks at night, menthol…so, I called a pharmacist (compound) locally. My PCP and pharmacist are going to create a cream with those two ingredients…brainstorming with them now. This neuropathy is so different and distinct for everyone, yet so the same, it is frustrating. My pain is 24/7…at night with the help of 10 mg zolpidem, Vicks, warm socks, soothing music, mediation…I can usually get 6 hours of sleep. What I think is sad…is when I wake up - the only thing that keeps me going through the day is , knowing I will get 6 hours of restful sleep later. Desperate in Florida..