It will add an extra 2 hours to your chemo time, so 7 hours might be longer than you would want. The infusion center at Mayo had heated blankets, which I use to help manage the cold. I’ve started asking for IV Benadryl as part of my premeds, which helps me to not care as much about the initial discomfort. It is uncomfortable for sure at the beginning. Every single time I ask myself, “Why am I doing this?” During the first few minutes. But, it passes, or you get used to it, and so for me, it’s not that bad. Manageable, compared to a lot of other things that we have to endure.