I listened to the podcast posted a few days ago by Dr. Patterson from the foundation of PN. It has a variety of causalities listed and new tools for testing described. She also elaborated on metabolic syndrome and patients with historically high triglycerides, and subtle toxic effects of obesity due to body fat content. These issues hit home as I have been diagnosed with idiopathic PN and have had EMGs at Norin and Mayo earlier in the beginning stages of the disease. I continue to read this thread hoping for a breakthrough but realize that the body chemistry and Genetic background, in addition to viral history poses a huge mountain of complexities that AI may have to resolve. Your best physicians and Neurologists have NO reliable answers! As I continue to examine the reports of others having success with B12 and extremely soficticated concoctions of multi vitamins, I can only conclude that these folks were deficient of the offered range of ingredients and were actually helped as the remedy matched the deficiency adequately. My numbness and burning began in my big toes on both feet in 2007. I had all the tests for deficiencies and auto immune diseases. Because my mother complained of it and told it was IPN, Neurologists claimed it is likely familial and genetically related with no solution or remedy. Since I listened to Dr. Pattersons podcast, I decided to review my triglyceride test history and found they were high or elevated for several years between 2007 and 2012 the seemed to level off. That makes me wonder?