@2brussels I was diagnosed with CPPD, also called pseudogout and pseudo rheumatoid. I started plaquenil 6/5/2026 and haven't had any side effects. It takes 3-6 months to start working. Up to 12 months, I've read. I have chronic CPPD so I don't swell up like you do. X-rays will show the crystals of CPPD, also an ultrasound or aspiration of the swollen joint. I was misdiagnosed for approx. 14 years. You have to find a doctor/rheumatologist that has experience with the crystal arthropathies. Not all do. My third rheumatologist diagnosed me. Good luck and let us know what you find out. Reiterating...the plaquenil takes months to work and you need an eye exam yearly.