I was diagnosed with high risk osteoporosis in July of 2025 . I was put on Evenity in July 25.
By December of that year I had thyroid levels go up increasing my dosage of Synthroid . My kidney levels rose and have to be measured ev 3 mo . And my blood pressure meds doubled as I began having fluctuations in BP and they were very high . In March of 2026!my internist said I needed scans to check liver and kidney. Reports indicated that I have abnormalities that need to be watched.
In November25 I began having SI joint problems. Ortho did MRI and said diagnosed with sacroillitis. Had to have steroid injections to relieve some of the pain .There were days I could barely walk .
On my annual vision exam in July of 26’ I was told I have a detached retina and macular
Degeneration in intermediate stage . Had a clear visions exam in July of 25.

In July of 26’ dexa showed that
my spine lost density bone etc so Evenity did not work for me .
Through out the year I kept saying to my rheumatologist and my internist,Is this coincidence that since I started
Evenity last July of 25 , all of these issues have developed .
They say it isn’t the Evenity causing the issues . I’m not so sure ! I did report all to FDA and Amgen and have not heard back . From what I’ve read on Social media medical sites there are many others with similar issues.
My dr and his PA vehemently said I need to go on Tymlos . And after reading about this drug I don’t like the possible side effects including development of bone cancer. I refused Tymlos . My internist agreed I should as well . I requested Prolia and was told rheumatologist PA that it will not work for me and waste of time as it won’t build bone like Tymlos . I insisted on the prolia injection and next July I will see if dexa improves from prolia, vitamins, and resistance and weight bearing exercises .
And hopefully another treatment is on the horizon at that point .
Good luck in your decision .