Three rounds of Xifaxan, works for a little while but not a cure. It took me two years of careful monitoring and a very good, science-based dietician to zero in on my problem, which is inability to digest certain types of fats, esp long-chain fat digestion…. once you get to the root cause of your troubles, you can manage this. I was prescribed Zenpep, which is another very costly prescription, but I have been able to manage my symptoms with diet and with dietary enzymes from Pure Encapsulations, they make a cheaper version of the Zenpep. Dosage is not as high as Zenpep, but I can actually adjust as needed with 1, 2 or 3 pills if I’m going to eat something that might trigger symptoms. Hope this helps.