Hi...I am on plaquenil and have been now for six months. I haven't seen any change in my joint pain so I went off it with my doctors suggestion to see if I felt worse off it. I did! So I'm back on it again. Guess it is doing something but I am still in quite a bit of pain in my body in general, hands and back in particular. My diagnosis is not clear, RA was diagnosed by a doctor in January who then left the practice and I have seen two more since who are not sure it is RA but definitely osteoarthritis so they just said stay on it. Can't take anything for the pain as my kidneys are not functioning great so only tylenol which does nothing. Very frustrating!! Seeing yet another rheumatologist in February of 27, my hospital can't seem to keep a full roster of docs for some reason. Wish someone could figure out exactly my diagnosis with clarity and find something that gives me relief. Best of luck to all of us who are working hard ourselves to feel well again...