@trina24 - Another member @19okie2 mentioned thigh pain and Actemra infusions this discusion - On Actemra, experience slight rise in CRP: https://connect.mayoclinic.org/discussion/on-actemra-experience-slight-rise-in-crp/

@trina24
Hi, Trina. I just got diagnosed with PMR this summer, after months and months of intense THIGH muscle pain in both thighs (the tops/fronts). First reaction was blame it on the statin. DQ'd the statin; no change. I was constantly massaging the tops of my thighs during the day; pain increased significantly during the night; also sometimes experience stabbing pains on lower thigh area (above knees). PA suspected PMR as joints weren't involved (but I've had trochanter bursitis for several years); CRP and Sed Rates were normal but antigen results were not. Am on prednisone trying to wean down to 2.5 every day. Thank you for mentioning the thigh pain as no one else seems to pinpoint that as their area of pain. It was a relief to get a diagnosis; it fit, made sense, and the prednisone works. I find staying active/moving around helps so much especially just after getting up in the mornings; but cannot push it like all day long or I pay for it the next day....