@babs1956 the side effects from Tagrisso can be difficult (especially without an end point), they were for me, too. sorry to hear you're having progression and side effects still on 40mg. for what it's worth, my oncologist thought 40mg wouldn't be enough to be effective. so we're planning to try surgery and see if I can stay off of it - at least for awhile. would the Aliya ablation procedure be an option for you?

@babs1956 I thought I might chime in as I’m on Tagrisso 80 mg since late February 2026 and I tolerate it well with minimal side effects. My first month I got a forehead rash but with antibiotic lotion, it went away and never returned. I also had some skin splitting by my nails but that also went away. Tagrisso crosses blood brain barrier and has been shrinking my brain mets and also my original lung mass a great deal. I understand, however, everyone is different. Facebook has a Tagrisso group and also EGFR group of folks on various treatments. I’m EGFR Exon 21 L858R. I was on chemo and stopped and now have progression and probably a different mutation, since the Tagrisso continues shrinking my original mets. I’ll get a biopsy this week to see. But with EGFR —targeted meds are typical to treat, plus chemo and/or radiation.