@bigtoe No ADT, which is how many neuro-endocrine cases arise - but even that scenario is after long term treatment and usually castrate resistance.
You should have your surgical biopsy revisited to look for these aggressive cells.
Also, I believe there are genetic tests which can point out mutations which may give rise to aggressive disease.
There is a lot more info you need to gather before making the leap to this serious conclusion. Best,
Phil