← Return to Looking for weight loss support & spotting false advertising

Discussion
Comment receiving replies
Profile picture for gualkeml1 @gualkeml1

@louiserivers
Obesity is fundamentally a chronic neuro-metabolic disease driven by brain signals that instruct the body to store more fat than necessary. Modern weight-loss medications work by recalibrating these internal energy-management signals, allowing the body to settle at a lower baseline of stored fat. Because it addresses underlying biology rather than short-term habits, managing obesity requires lifelong treatment—a sustained effort that plays a critical role in preventing severe, potentially fatal conditions such as heart attacks and cancer.

Jump to this post


Replies to "@louiserivers Obesity is fundamentally a chronic neuro-metabolic disease driven by brain signals that instruct the body..."

@gualkeml1
Amen! This is exactly what I’ve read in the book “Enough”.

For the past 40 years I’ve tried to lose weight by calorie restriction + exercise. I could lose 60-70 pounds but I would always gain it all back.

My body has a “body fat set point”. Brain is wired to hang onto more fat in case there’s a famine. Crazy!

Obesity was declared a disease in 2013. I wish I would have heard that news back then instead of constantly beating my head against the wall.

I’m excited for the future of these new weight loss meds which are beginning to rival the same amount of weight loss as Bariatric surgery has had in the past 30 years!

I take weekly injection of Mounjaro 15 mg (top dose). The half life is 5 days. I told my endocrinologist that I can tell when the Mounjaro is reaching the end of its weekly effectiveness = about 2 days before my next weekly injection. I get more “food noise” and cravings. She said she had heard this same thing from her other patients.

Research and FDA trials are being done on a future med which will last 21 days. Plus they’re working on meds which target more than just GLP-1 and GIP hormones, like glucagon.

All of this wonderful info I’ve learned from the book “Enough”.

I love knowing the details behind my health issues because it motivates me to be proactive and work with my health care team to strive toward better health.