My wife has been on Rasonque (daraxonrasib) for about 6 weeks now. She has had a similar diarrhea side effect that you describe. The oncologist started out with imodium and then added lomotil (a strong prescription drug). She is supposed to take imodium as soon as the diarrhea hits, and the lomotil up to 4 times per day. She has also begun taking creon-type pills with every meal. The diarrhea is pretty uncontrollable when it hits, usually soon after eating. So far no solution has been found to stop it. A typical next step is to reduce the Rasonque from 300 to 200mg. Her oncologist is reluctant to take that step because her cancer markers are falling alot. (from 13,000 to 3,000. She will have her first post-Rasonque scan in early October. If diarrhea is still hitting hard at that date, I will push hard for the reduced dose.