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Profile picture for Jeff Marchi @jeffmarc

@pesquallie
I know of lots of people that have had either full recovery or significant recovery after you being on ADT. Yes, if you are older, it can be more difficult. I’m 78 and have no major problems with Lupron. In my case, at 77, I stopped taking ADT and in eight months my PSA rose to 50, Going up 25% a month at that point. That was after being on ADT for seven years. I did have to go back on ADT because of my aggressive case. I don’t think it’s slowed me down at all.

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Replies to "@pesquallie I know of lots of people that have had either full recovery or significant recovery..."

@jeffmarc Eight months to still be at castrate level (50) may be okay for metastatic patients who expect to be on ADT for life but will not inspire confidence for someone contemplating a 6-month ADT course if it will take 16 months or more to recover. Testosterone increases tend to plateau so it is unlikely that a low (300) testosterone level would be achieved in another 8 months (25% per month). Anyone over 75 should know the long-term risk of Lupron if taken for short term (vs permanent) ADT, especially since Orgovyx is as good with a better recovery profile. Even with Orgovyx the risk of poor and slow recovery is higher over 75 than at younger ages. Doctors tend to minimize this risk.