@julieahp
P.S., I meant to add that after being on Tyenne infusions for ~ 2 years, I am now switched to Avtozma infusions and have had 1 infusion so far and haven't noticed any difference. It's a newer American-manufactured biosimilar that Kaiser Permanente has switched to for this GCA/PMR diagnosis and likely easier to keep supplied now.

@julieahp Thanks for this thoughtful post. I, too, have been getting regular vaccinations for flu and Covid. Like you, I space them a couple of weeks apart. I was in public health, and we were taught to aim public health messages at the general population where they will have the greatest impact, which means they may not be appropriate for people with extenuating conditions. After discussing vaccinations with my pharmacist, I also opted to get the regular flu vaccine each year, not the senior formulation which contains an adjuvant to boost the immune system. He also counseled the Covid vaccine by Pfizer over Moderna because it is less likely to cause a reaction but is equally effective. For some reason that I don’t understand, my now retired PCP did not recommend the shingles vaccine, and now that I am getting a new doctor, I would like to get one. While withdrawing from prednisone from a flare, though, I apparently had prednisone withdrawal which was unrecognized until it triggered secondary adrenal insufficiency which I am now fighting. I am really uncertain about the effect of any vaccines on my slow recovery. Do you go up on your dose prior to having a vaccination? And you said you had a pretty strong reaction to it — was that related to PMR?GCA or was it the side effects that are typical of the vaccine?