← Return to Prolia adverse events over 10 years - ONJ, AFF

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Profile picture for Michael Lavacot @michaellavacot

Hi @2connie - I have no insight here. I will say that Prolia, like other medications, reduce your risk of fracture but does not eliminate it. Hopefully you did not fracture and it's just a pinched nerve or something. Perhaps do some lower back stretching to ease the nerves that run through your spine down toward your lower extremities. I hope everything works out.

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Replies to "Hi @2connie - I have no insight here. I will say that Prolia, like other medications,..."

@michaellavacot
I have been treated for osteoporosis across the last 20+ years starting with oestrogen, then Fosamax, strontium & Prolia from 2014. Prolia was the only drug that increased my bone density. I didn’t have any side effects that were noticeable apart from possible blood pressure spikes after the six monthly injection. At the ten year mark my endocrinologist decided to take me off Prolia. In hindsight this was a bad decision & probably was a result of four of her patients suffering an AFF. I had an Aclasta infusion to supposedly hold the bone density gains but this was not successful. My DEXA after one year showed a 14% loss in the spine & a 12% loss in the hip. I had never been in the osteoporotic range in the hip so was devastated to see this. I was offered Tymlos, Forteo or Evenity (all subsidised by the Australian government). I have chosen Evenity as I believe it may give me greater gains in the hip than Tymlos. Ironically, she is suggesting that I go back on Prolia after twelve months of Evenity. It will be a lifetime drug. I’m 75 & apart from a few fractures ( including a spinal compression after going off Prolia) & needing a knee replacement next year, I am fit & healthy. I’m not really daunted by the thought of staying on Prolia as I didn’t find it a problem. I just wish that I’d never been taken off it.
Sorry for the long post but I thought it important to flag what may be the reality for those thinking of transitioning off Prolia.