Dr. Paul Schellhammer, a urologist who was diagnosed with PCa several decades ago, took transdermal estradiol, a.k.a. tE2, as his primary ADT drug. tE2 lowers testosterone as effectively as Lupron but one of its side effects is a higher incidence of breast development and nipple pain than Lupron.

He had nipple pain.

His pain was severe and sustained enough that he had a surgeon cut the nerve that takes the pain signal to the brain.

The procedure, he says, is called a "neurectomy of the anterior branch of the T4 nerve" which completely resolved his breast discomfort successfully.

When speaking about this he made it sound like the pain is gone and he has no regrets. His context was this pain and the treatment for it was a small price to pay for not having to endure all the side effects of Lupron that had bothered him when he took that drug instead of tE2.

I'd think that cutting a nerve would tend to cause a bit larger of a numbed area than just the nipple. However, if I experience serious nipple pain at some point this is a procedure I would look into.

Schellhammer's recorded remarks about this are part of a video interview:

Another post I saw mentioned "applying a small amount of topical diclofenac (Voltaren) gel daily" that a guy said he used for "mild nipple tenderness" caused by ADT hormone imbalance. He mentioned that he had received prophylactic radiation to his breast buds prior to going on tE2 as his ADT drug. See:
https://www.prostatecancersecrets.com/p/my-amazing-response-to-estradiol