@dsf71 I have been on Letrozole for four years. Initially I was told my life expectancy was 1-2 years. However, I have now lived for four years, and my oncologist said my odds improved at about two and a half. I credit the Letrozole completely. I have had absolutely no side effects, and my bone density remains normal. Obviously it isn't tolerable for everyone, but I wanted to share a success story.