@mjb24 You are so welcome. I've tried a lot of supplements and never felt anything-at all. I would add the NMN before the CoQ10. Vitamin D3 is also so important for us with BE! I hear you loud and clear about not taking any medications and supplements "before". As I said, I have tried other supplements before but never felt any difference in comparison to what I have felt with the NMN-which is why I wonder if I'm experiencing a placebo effect, I read the studies and I'm feeling the same outcomes exhibited in the study results. I would suggest doing some exercise or endurance tests prior to starting and again at 2- and 4-week intervals and if there is no change - you have adequate NMN without the supplement. I did the sit stand timed test (or chair test) and noticed a significant improvement. Best of luck to you and please keep me posted. Kathy