What I'm about to share here on TRT is 100% strictly anecdotal, but I think that it is nevertheless, worth noting:

I was diagnosed with aggressive prostate cancer and treated extensively in 2018. My PSA remained undetectable for 8-years, and my total (blood) testosterone levels, consistently idled below 200 ng/mL, for almost 7-years. However, my physical strength had been significantly impaired to the point that lifting my toothbrush seemed a chore! It was exceedingly difficult to conduct normal physical activities. And so, after 6-years of what appeared to be complete remission, I contacted my original oncologist for his thoughts.

He stated that given my treatments, history and good testing results, I would qualify as a perfectly reasonable candidate for TRT (testosterone replacement therapy), via single, bimonthly injections of 200 mg Testosterone Cypionate.

And so, I did so, for a period of approximately 4-5 months (8-10 total injections). By 3-4 months later, my total testosterone (in blood) levels were reading 425+. A very nice improvement, yet in terms of actual strength, it didn't seem to be very noticeable? So, in October 2025, knowing full-well the link between testosterone and prostate cancer, I decided to simply quit the injections. Just 4-months later (January 2026), my PSA shot-up to 3.0+, and now (8 more months later), my cancer is in recurrence, with a positive PSMA-PET scan and a PSA of 13.4.

Did the TRT injections positively cause the return? I'm told by multiple sources (all of whom know a great deal more about such things than me), that it's unlikely, but I will probably still wonder, most all of my life.
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"When I was younger I believed,
That dreams came true.
Now, I wonder.

When I was younger I believed,
That I could win.
Now, I wonder.

I keep on searchin' for the old me,
I keep on thinkin' it’ll change.
I keep on hopin' for a new day,

Will I ever,
Feel the same?
Now, I wonder.

Oh, I wonder."

(Chris Isaak)