Some people tolerate methotrexate well, and some have a lot of side effects. My brother-in-law has been taking it for 14 years to treat PMR, and he hasn't had any problems with it.

I've been taking Actemra for more than 2 years. Actemra and Kevzara both block IL-6. I haven't had any side effects from the Actemra, other than some minor fatigue following the first few injections. I have a Medicare Advantage plan that pays for the Actemra with prior authorization. There is a limit this year of $2100 out of pocket to cover all medications. I think in January that will go up to $2200. If you are already taking some other expensive drugs, the Kevzara wouldn't add a lot to your expenses.

Also, depending on your income and insurance policy, there are copay assistance programs for people that take Kevzara and Actemra. Their manufacturers both have programs, and there are also other programs. Anyone who is interested can find more information online.