@corneliagd ~ I've had neuropathy in my feet that started getting really painful about 10 years ago. For the past 4 years, I've been taking Lyrica (75mg 3x/day) because nothing else worked until recently. I started taking low dose Naltrexone (LDN) in June - 1.5mg titrating to 4.5mg. Currently I'm taking 2.5mg once a day, but have a new prescription for 3.5mg. Already, it has almost completely eliminated the burning, tingling and sharp stabbing pain in my toes and balls of my feet!! And I haven't had to use any of the topicals or anything else! Believe me, I've tried it all to get relief over the years.

Many doctors aren't aware yet that LDN is being used "off label" to treat chronic pain of various kinds, including neuropathic pain. At higher doses (50mg and up) it is used to treat opoid addiction. LDN has to come from a compounding pharmacy (not CVS or a drug store or grocery pharmacy) and requires a prescription. Side effects listed for it are minimal and resolve quickly (mild nausea or "vivid dreams"), but I've had NO side effects at all. It doesn't lead to any weight gain and fatigue the way Lyrica and Gabapentin do, nor is it addictive. I'm hopeful that by the time I get to the 4.5mg dose, I'll be able to wean off of Lyrica completely. But so far, I'm really happy that the LDN is working so well to relieve my pain!! I'm happy to answer any other questions about my experience with LDN. Best wishes to you!

P.S. - It's not exactly inexpensive. I pay $110 for a 90-day supply. But considering all of the money I've spent on topicals, vitamins, supplements, you name it, to me it's worth it because it's working! I've stopped taking the ALA, magnesium glycinate, everything, and swear by LDN! It's FDA approved for treating chronic pain. The websites that reference it are as follows:
* https://www.clevelandclinicmeded.com/showcase/EKCC138/docs/1430_Hill_Dose.pdf
* https://ldnresearchtrust.org/