@biggalew Have you found a doctor that will prescribe Orgovyx? It might be hard unless you are very old. If you have trouble just say you are exploring radiation and a urologist will prescribe it to arrest further development. It is definitely the best ADT drug. Everyone on it has some bone and muscle loss even when actively doing resistance exercises and taking supplements to minimize the losses. Over half have hot flashes and/or night sweats. A minority have breast tissue development. An alternative is Estradiol patches. That eliminates the bone loss, hot flashes, etc. but has over 50% breast development.

If you do not find a doctor that supports the unorthodox treatment you desire wait a few years. When the cancer goes metastatic it becomes an orthodox treatment, probably combining Orgovyx with an ARSI.

@biggalew If it were me with PSA at those levels and doubling in a year, I would definitely want to contact an oncologist or even a couple of really good ones. As to what they will recommend in your case, I will leave that to them.

@biggalew I would insist on a top tier GU Medical Oncologist as opposed to a garden verity Medical Oncologist.