@tarakeeg - welcome to Mayo Clinic Connect. That's rough that your tirzepatide (Zepbound) is having very little or no effects.

I moved your post here where another member was talking about a similar situation with tirzepatide (Zepbound):

- GLP1 and no weight loss https://connect.mayoclinic.org/discussion/glp1-and-no-weight-loss/

Fellow members here such as @sandylakes @celia16 @samwho and others may also have some input on being what you called a slow responder.

I am not a medical professional, but personally, I, too, have dealt with this. I took tirzepatide (Zepbound) 2 years ago when I lost 53 pounds on semaglutide (Wegovy), but had terrible GI side effects. I got all the way up to the top dose of tirzepatide (Zepbound), and my insurance said I'd maxed my coverage. I had only lost 1 pound on it by then.

My husband did not lose any weight on tirzepatide (Zepbound) till he got to the highest dose.

What does your medical professional overseeing your care say about this lack of effect so far?

@tarakeeg I also struggled with losing weight at 10 mg a week, so my doctor increased the dose to 20 mg a week. I still am a slow loser (4 pounds a month), but my weight loss is steady. Maybe ask for an increase.