← Return to Gastroparesis: nausea, lightheadedness or occasional vomiting

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Profile picture for jneener @jneener

I have severe gastroparesis and can't eat enough to maintain so I am on TPN therapy. I suffer from chronic nausea but am allergic to almost all the medication they prescribe for it: reglan, zofran, compazine, promethazine, scolpamine patch, hydroxyzine and even THC. Is anyone aware of any other antinausea medications or even off label medications that help.

A little history, I was diagnosed with gastroparesis in January. Prior to waking up in December 2025 and unable to drink water, I was perfectly healthy with no symptoms. By February they did Gpoem surgery after only doing 2 tests to say I had gastroparesis. The gpoem itself worked but didnt address my inability to eat. That's were the TPN comes in. They have done no other tests and said I need a neurogastro motility specialist but I can't find one to take me. They said my gallbladder was bad and just took that out. If it wasn't for my PCP trying to help me, I dont know where I'd be. By the grace of God I am alive and want to continue to thrive.

If you have read all this, thank you and if you know of any other antinausea meds that might be worth trying or even a neurogastro that could help me, I welcome your insight.
Thank you.

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Replies to "I have severe gastroparesis and can't eat enough to maintain so I am on TPN therapy...."

@jneener - welcome to Mayo Clinic Connect. Having a tough time getting enough nutrition and also having chronic nausea, and no remedy due to reactions to the nausea medications, sounds really rough.

Here is some Mayo Clinic information on this condition that may be useful:

- Gastroparesis https://www.mayoclinic.org/diseases-conditions/gastroparesis/symptoms-causes/syc-20355787

I am glad that you like the work your PCP has done trying to help you. If you have any other avenues of finding the specialist your GI medical professional suggested, it might give you a second opinion that would be useful and help ease your mind.

What kind of reaction do you have when you take the antinausea medications you listed? Does your GI team or your PCP have any other suggestions for antinausea medications or techniques that might help you?

@jneener
I know this sounds weird but it helps my nausea. When I have nausea I get a couple alcohol pads/swabs (rubbing alcohol) and smell it for a few minutes,for some reason the smell of rubbing alcohol makes my nausea go away. Peppermint candy/gum also helps my nausea.