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GLP-1 Drugs Effects on PMR

Polymyalgia Rheumatica (PMR) | Last Active: 6 days ago | Replies (64)

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Profile picture for zendaysahead @zendaysahead

@randersonccc I've been struggling with PMR for 10 years and on 5mg Prednisone daily. Every time I try to taper off I relapse and it takes months to get back in pain control. So I'm specifically interested to know if you think GLP-1 helps with PMR muscle pain & stiffness?
A woman in my dance class was scheduled for hip surgery but wanted to lose some weight before and got on GLP-1. She discovered all her hip pain went away - she thought it may be from the weight loss but when she got off the GLP-1 3 weeks later the pain returned. She now takes GLP-1 once every 3-4 week and is pain free. I'm very interested to see if it help with PMR as I'd love to taper off the prednisone. The future looks promising. Thanks.

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Replies to "@randersonccc I've been struggling with PMR for 10 years and on 5mg Prednisone daily. Every time..."

@zendaysahead I've been on a GLP-1 on and off (mostly on except for a three-month break) for almost three years. I have had various muscle, joint, and nerve issues before and during that time. I have never felt that the GLP-1 had any effect on my pain/stiffness levels. (Terrific for suppressing appetite and increasing fullness, though, as advertised.)

I was officially diagnosed with PMR 3 months ago, but my best guess is that I had it for at least two years before that. Of course, that's just me and my mix of issues.

On a related topic, both my primary and my rheumy feel that a GLP-1 and prednisone are a good fit. I've read a few articles that say the same, and a few that sort of casually disagree, but haven't done a deep dive yet.

Good luck.