@stonewheel

I don't think there is a significant difference between Kevzara and Actemra. The Actemra biosimilars probably work well too. I stay on Actemra because that was what I started with and it continues to work for me. I have switched from Actemra injections every 2 weeks and increased to weekly injections. I now do a monthly infusion of Actemra and that has some advantages that I like. My rheumatologist doesn't mind if I do the infusion one week early which I rarely do. When my schedule doesn't allow for an infusion exactly at every 4 weeks, I do it at 5 or 6 weeks. I have gone as long as 7 weeks between infusions but that is a little too long . I don't have a full blown flare but my pain increases a little bit and my inflammation markers become slightly elevated.

I transitioned from Actemra to Humira and back to Actemra without any problems. There weren't any gaps in treatment. When it was time for my next dose of Actemra, I did a dose of Humira instead. It was the same when I switched from Actemra injections to a monthly infusion. When it was time for my next injection, I did an infusion instead.

The nice thing about an infusion is that it is weight adjusted and can be given in any dose. My infusion dose has been adjusted by the doctor a few times. My rheumatologist asks me if the current dose is good for the whole month and he can adjust my dose up or down accordingly. Nothing changes too much so I get the same dose most of the time. The dose of an Actemra infusion can be either 4 mg per kg but can be as high as 8 mg per kg of body weight. I currently do 600 mg every 4 weeks.

Doses exceeding 600 mg per infusion are not recommended in GCA patients. I have PMR but I'm treated "as if" I have GCA.
----------------------------------------------
https://www.drugs.com/dosage/actemra.html
----------------------------------------------
"The recommended dosage of ACTEMRA for adult patients given as a 60-minute single intravenous drip infusion is 4 mg per kg every 4 weeks followed by an increase to 8 mg per kg every 4 weeks based on clinical response.

Reduction of dose from 8 mg per kg to 4 mg per kg is recommended for management of certain dose-related laboratory changes including elevated liver enzymes, neutropenia, and thrombocytopenia."