Swelling of the ankles and legs is a well-known side effect of amlodipine. This happened to my husband when he was prescribed amlodipine, he'd never had issues with that swelling before the amlodipine. We weren't thinking of the side effects of the drug, his mother had had serious issues with venous insufficiency in her legs, and fearing this was happening to him, my husband went to see a venous surgeon about this. He didn't have that, thank goodness, and when she asked him about the medications he was taking, his mention of the amlodipine solved that mystery of the leg/feet swelling. He stopped taking the amlodipine, it was replaced by another medication, and his swelling disappeared.