@sabwal I'm about to start on Lenvima and Keytruda for stage 4 serous carcinoma endometrial cancer. It will be my 5th type of chemo. First in pill form so anxiously awaiting how well I tolerate the side effects, that sound promising by the way. I had my hysterectomy in Aug 2025. I've never had radiation, only chemo. I never got sick from the chemo treatments. I had 21 total. Different kind. Carboplatin and paclitaxal first. After surgery was found to be HER2 positive to Herceptin was added to the carbo/taxol. Didn't work so started Enhertu which was a stand alone treatment. Didn't work. Started doxorubicin and had 3 treatments of that. The 4th was actually scheduled for today, Aug 27th, but after PET results it was determined it would be useless. Oncologist and my oncologist/surgeon, who's working with her, decided to try the Lenvima and keytruda. There's always hormone blockers since my tumors were hormone fed but I'm just praying this treatment will make a difference. My point is, there's no way I would have stopped after the first treatment did not work. Nor the 2nd, 3rd, or 4th. I will keep trying until we find something that works, if it only buys me a little more time, or until we've exhausted all options. I would at least try a treatment ONCE, maybe twice, before throwing in the towel. I was 67 when diagnosed so age could play a factor in deciding. Not everyone suffers with chemo treatments.