@29modela Same for me. I had gone down the Cyberknife road in 2013 with a PSA of 13 and Gleason 7's. In 2021., however, my PSA was only 1.5 and my Seattle Oncologist was "suspicious" and suggested a new biopsy. Local urologist almost laughed me out of his clinic with a 1.5, but agreed to do it. He stopped laughing when my new Gleasons came back as 8-9, sending me back for a second round of Cyberknife in 2021. So yes, you can absolutely have a low PSA with a higher grade of cancer. Don't let any of your doctors/urologists/friends tell you otherwise.