@rpec Home Health will come out about once a week and check your vitals and will change the dressing where picc line is. The antibiotics I have done at home with picc line is fairly easy. They will show you how to do it. You just take vial with the antibiotic, attach it to picc line and squirm it right in. Some I have done once a day and others twice a day. There is only one that I had a bad reaction to and had to stop and that was cefepime. Hope it works out for you. When are you going to start the antibiotic?