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Low psa , high cancer grade

Prostate Cancer | Last Active: 4 hours ago | Replies (40)

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@jeffmarc
Hi Jeff, I always value your insight and I wanted to follow up with your regarding your reply to this thread. I'm hopeful you can share your thoughts as I was very encouraged to hear you say you know a lot of people with grade group 5 who have been alive for well over 10 years. Briefly, my numbers are: I was diagnosed at 56 years old. PSA 13.2 followed by prostate biopsy. Biopsy results: 8 cores = grade group 4; 4 cores = grade group 5. Cribriform morphology present. Perineural invasion; intraductal spread / intraductal carcinoma identified. I don't have a great idea about survivability, curative scope or duration of treatment other than I've completed radiation treatment and am on ADT + abiraterone (you've replied to some of the cardiac issues I have experienced from abiraterone) for two years. My oncologist says she believes it's curable. I struggle with the veracity of this statement and hope to get additional information from you. I value your input.

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Replies to "@jeffmarc Hi Jeff, I always value your insight and I wanted to follow up with your..."

@corin
I wish there was a simple answer to this, but medicine has not come up with a way to treat both Cribriform and intraductal successfully.

Did they say that it is large cribriform? That one is more aggressive and is a bigger factor.

They can treat the combo with radiation but the long-term results are uncertain.

I suspect you might want to be informed as much as possible about what’s going on in The treatment for these issues. Here are a few places that get into it in detail.

Here’s links to two videos that discusses treatment for intraductal.
https://pubmed.ncbi.nlm.nih.gov/40186732/
Intraductal video


Here’s a couple of videos that discuss treatment of both issues
https://connect.mayoclinic.org/comment/1612121/