@mcharlesfrancis CT scan was brought forward and showed improvement. essentially compared to the previous one taken 2 months ago there has been additional reduction on main lesion by an additional cm. so essentially diameter has halved since beginning of therapy. liver still clean and lungs further improvement. I was very happy about it but I guess 13 points in CA19 are not visible in scan; I guess main thing will be monitoring it closely during this chemo holiday. thanks for your feedback so far.