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possum1969 avatar

Hypothyroidism and orgovyx.

Prostate Cancer | Last Active: 12 hours ago | Replies (30)

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Your interaction with the “3 female therapists” was due to your low testosterone caused by the Orgovyx. “Male menopause” is what they call it. (Your doctor should have explained the side-effects to you well before you started the androgen deprivation therapy.)

Many men experience side-effects to varying degrees — some more, some less —> mood swings, emotions, anger, irritability, confusion, fatigue, loss of libido, hot flashes, night sweats, muscle atrophy, loss of strength, and weight gain; sometimes memory loss, forgetfulness, depression, ED, and more….

These menopausal-like side-effects will be greatly minimized/avoided if you engage in a rigorous load-bearing exercise program (resistance-training, weightlifting, TRX, your own bodyweight, etc.) to offset the metabolic side-effects of ADT. (I avoided most of the typical ADT side-effects; the ones that I did experience were quite tolerable.)

Also, your doctor should have discussed with you any possible drug interactions (levothyroxine in this case).

Were you engaging in a rigorous resistance-training exercise program prior to starting Orgovyx?

Most side-effects of ADT are easily minimized/avoided with resistance-training exercise. Here are just a few that I’ve bookmarked:

> Drs. Scholz and Moyad talking about exercise and hormone therapy (at a virtual PCRI conference): https://m.youtube.com/watch

> A paper on The Benefits of Exercise During Hormone Therapy: https://static1.squarespace.com/static/54c68ac6e4b06d2e36a4b8c9/t/55cb7275e4b0d97ae7ff60af/1439396469154/The+Benefits+of+Exercise+During+Hormone+Therapy_Insights+August+2015_PCRI.pdf

> A study about the benefits of exercise to counteract the adverse effects of ADT: (They describe a good resistance-training program): https://journals.lww.com/acsm-msse/fulltext/2023/04000/resistance_exercise_training_increases_muscle_mass.2.aspx

If you do what it takes, you’ll do very well with the hormone therapy side-effects - it’ll just be an annoyance.

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Replies to "Your interaction with the “3 female therapists” was due to your low testosterone caused by the..."

@brianjarvis Thank you for your comments. Yes the doctors should have and no they didn't. By doctors I mean the urologist and cancer doctor. When I mentioned that I had looked up the TSH being so high because of orgovyx taken so close to levothyroxine, he sorta brushed me off and said that if that was the case then my T4 would have dropped. When I asked my primary doctor if she thought the combination being so close together caused the spike she said that she was certain that was the case. Only 2 cases that I could find on this issue. Probably being orgovyx being a fairly new drug. I only googled orgovyx, not any ADT. I don't want to get into a boxing match with the doctors. Thank you again.

@brianjarvis When I broke down in front of the therapists I am sure the cause was from taking orgovyx an hour after taking levothyroxine. Then I started googling the reasons why I did that. One reason was "medications". I read where orgovyx should be taken at least 6 hours after thyroid medicine. Then after my lab work, 3 days after last treatment, TSH was 35. I asked the pharmacist if there was any interaction if I took orgovyx and levothyroxine. She said that she couldn't find any. I should have asked if there were any interaction if I took them within an hour of one another. My concert doctor seemed to think there was no problem with taking orgovyx an hour after thyroid medicine so he was unaware. I have yet to talk with my urologist. When I asked my primary doctor if I should separate the meds, I already did 2 weeks before, she told me to separate. Later I asked her how certain was she that orgovyx taken too soon after thyroid medicine, she told me very certain. If there were only 2 cases involving orgovyx and levothyroxine, not sure they would know. This drug was trialled in the UK and only here since 2021. Thank you for the info on exercising.