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GLP-1 Drugs Effects on PMR

Polymyalgia Rheumatica (PMR) | Last Active: 9 minutes ago | Replies (51)

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I started Zepbound 10 months ago. First for weight loss. But, immediate change in 2 things. Less stiffness and better movement of shoulder and hip and knees bilaterally. Then my CPAP events per hour went down to 2 or 3 over 7 hours!! Now on what I call a maintenance dose of 2.5mg Zepbound after a 45 pound weight loss and CPAP events per hour a still good. Also on 2mg per day of prednisone and Actemra inj weekly. I am maintaining well and am able to do and join most things I want to. I’m 78 and I don’t plan on changing much but I do also do the arthritis Tylenol 2 times a day. May try to lose my final 10 pounds of weight to reach my goal but overall as long as I have this condition I’ll stay this course unless they find a permanent solution to our PMR. ☺️r

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Replies to "I started Zepbound 10 months ago. First for weight loss. But, immediate change in 2 things...."

@randersonccc eight

I'm curious about the sequence of events. Was your extra 45 pounds of weight caused by Prednisone? Did the extra weight lead to obstructive sleep apnea and needing CPAP?

Was Actemra started before Zepbound so that you could begin to decrease your Prednisone dose down to 2 mg. Was Zepbound started by an endocrinologist to treat Prednisone side effects or did your a rheumatologist start Zepbound to decrease inflammation?

It sounds like you are going in the right direction. I'm just curious about how you were able to turn things around. What steps came first, second, third, etc. which allowed you to go in a different direction?