I had that regiment for 12 months. First 2 months were the most difficult with itching, fatigue, no appetitie, and dry mouth. But I continued through it before I had read the research and positive outcomes. Some symptoms decreased, but none increased. Eventually, appetite returned I gained weight, but the fatigue lingered. Not sure if data is correct but only about 50% of patient can take the regiment for 12 months. I am now in remission with surveillance every three months. My bladder however, continues to be inflamed and we are working on a future direction for that. Hope this helps.